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2i means the calculated theoretical additive radiosensitization effect of Gd-NTs and MbO 2 @NTs (assuming there was no synergistic effect), which was calculated by multiplying the survival inhibition ratios of Gd-NTs + RT and MbO 2 @NTs + RT according to the reported method 41

Nelson DB, Dc R, Niu J, Vaporciyan AA, Antonoff M, Hofstetter WL, Walsh GL, Swisher SG , Fa R, Giordano S, Mehran R, Sepesi B

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Citation: Davies, M., & Garvey, W

[97] In essence, mutations in mtDNA upset a careful balance of reactive oxygen species (ROS) production and enzymatic ROS scavenging (by enzymes like superoxide dismutase, catalase, glutathione peroxidase and others)